Amoxicillin-induced aseptic meningitis: 2 case reports and appraisal of the literature

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Prevalence of asthma and severity of allergic rhinitis comparing 2 perennial allergens: house dust mites and Parietaria judaica pollen.

BACKGROUND: Allergic rhinitis (AR) is an increasingly prevalent worldwide disease that has a considerable impact on quality of life and health care costs. Asthma and AR may be part of the same disease, with AR leading to an increased risk of asthma. OBJECTIVES: To assess the prevalence of asthma in patients with AR due to house dust mites (HDMs) or Parietaria judaica and analyze the characteristics of asthma and AR in each group. METHODS: Cross-sectional, multicenter study with recording of demographic and clinical characteristics. All patients had AR confirmed by symptoms and a positive skin prick test to HDMs or P judaica. They were classified according to the severity and frequency ofAR following the Allergic Rhinitis and its Impact on Asthma (ARIA) and modified ARIA criteria and according to the severity of asthma following the Global Initiative for Asthma criteria. RESULTS: We studied 395 patients (226 in the HDM group and 169 in the Pjudaica group) with a mean (SD) age of 43 (15.3) years. Using the modified ARIA criteria, we detected more severe and persistent AR in the P judaica group than in the HDM group (44.5% vs 24.8%, P < .001). Nevertheless, there were no statistically significant differences between the groups in terms of the severity or prevalence (50% in HDM vs 47.9% in P judaica, P = .685) of asthma. CONCLUSION: AR due to P judaica pollen, which behaves like a perennial allergen, is associated with the same prevalence of asthma and with more severe rhinitis than AR due to HDMs.

Prevalence of Asthma and Severity of Allergic Rhinitis Comparing 2 Perennial Allergens: House Dust Mites and Parietaria judaica Pollen

Antecedentes: La rinitis alérgica (RA) es una enfermedad de prevalencia creciente en todo el mundo, con un importante impacto en la calidad de vida, generando un elevado coste sanitario. La rinitis y el asma pueden ser consideradas como parte de una misma enfermedad y por tanto, la RA puede conducir a un incremento del riesgo de desarrollar asma. Objetivos: Evaluar la prevalencia de asma en pacientes con RA por ácaros del polvo doméstico (APD) y en pacientes con RA por Parietaria judaica y evaluar las características de la rinitis y del asma en cada grupo. Métodos: Estudio multicéntrico, transversal. Se registraron las características demográficas y clínicas de todos los pacientes. Todos los pacientes tenían RA confirmada por síntomas y pruebas positivas a APD o a Parietaria judaica. Los pacientes se clasificaron según la gravedad y la frecuencia de la rinitis siguiendo los criterios del ARIA y ARIA modificada y la gravedad del asma según los criterios de la GINA. Resultados: Se incluyeron un total de 395 pacientes, 226 en el grupo de APD y 169 en el grupo de la Parietaria judaica, con una media de edad de 43±15,3 años. La clasificación ARIA modificada nos permitió detectar que el grupo de Parietaria presentaba una rinitis más persistente y grave comparado con el grupo de APD (44,5% versus 24,8%, p<0,001). Sin embargo, no se obtuvieron diferencias estadísticamente significativas entre la gravedad y la prevalencia (50% en APD vs 47,9% en Parietaria, p=0,685) del asma en los dos grupos. Conclusiones: La RA por polen de Parietaria judaica, que se comporta como un alérgeno perenne, puede causar la misma prevalencia de asma y una rinitis más grave que APD (AU)

Background: Allergic rhinitis (AR) is an increasingly prevalent worldwide disease that has a considerable impact on quality of life and health care costs. Asthma and AR may be part of the same disease, with AR leading to an increased risk of asthma. Objectives: To assess the prevalence of asthma in patients with AR due to house dust mites (HDMs) or Parietaria judaica and analyze the characteristics of asthma and AR in each group. Methods: Cross-sectional, multicenter study with recording of demographic and clinical characteristics. All patients had AR confirmed by symptoms and a positive skin prick test to HDMs or P judaica. They were classified according to the severity and frequency of AR following the Allergic Rhinitis and its Impact on Asthma (ARIA) and modified ARIA criteria and according to the severity of asthma following the Global Initiative for Asthma criteria. Results: We studied 395 patients (226 in the HDM group and 169 in the P judaica group) with a mean (SD) age of 43 (15.3) years. Using the modified ARIA criteria, we detected more severe and persistent AR in the P judaica group than in the HDM group (44.5% vs 24.8%, P<.001). Nevertheless, there were no statistically significant differences between the groups in terms of the severity or prevalence (50% in HDM vs 47.9% in P judaica, P=.685) of asthma. Conclusion: AR due to P judaica pollen, which behaves like a perennial allergen, is associated with the same prevalence of asthma and with more severe rhinitis than AR due to HDMs (AU)

Topical dexketoprofen as a cause of photocontact dermatitis.

We reported on the case of a patient who developed a cutaneous eruption in a photoexposed area 1 week after a continous topical treatment with dexketoprofen (Enangel). Photopatch tests were positive for dexketoprofen, ketoprofen and piketoprofen and patch test was positive for piketoprofen. Control photopatch testing with dexketoprofen in 15 healthy volunteers was negative. Dexketoprofen, ketoprofen and piketoprofen are non-steroidal anti-inflamatory drugs (arylpropionic acid derivatives) often used as topical anti-inflammatory agents. It appears that the benzophenone moiety of their chemical structure is the cause of their photosensitivity and cross-photoreaction.

[Application of immunotherapy in Catalonia (Spain)]. / Aplicación de la inmunoterapia en Cataluña.

BACKGROUND: The aim of this study was to determine the use of specific immunotherapy (SIT) in public and private hospitals in Catalonia (Spain) in the management of respiratory allergic diseases and opinions about this treatment through a questionnaire. SIT dosage schedules and the creation of immunotherapy units were also investigated. METHODS AND RESULTS: A questionnaire containing eight items was sent by post and/or electronic mail to the heads of allergy units in 24 public and private hospitals in Catalonia.A total of 18 hospitals responded. The most commonly used route of administration was subcutaneous (89.4 %, SD 9.05) and the most widely used dosage schedule was the classical schedule (77.2 %, SD 24.9). Most of the hospitals (83.3 %) believed that immunotherapy units were an advantage but only 44 % of them believed that their creation was feasible. CONCLUSIONS: The results of this survey identify the application of SIT in Catalonia and reveal certain features of this treatment that remain to be established such as the optimal dosage schedule and the precautions that should be followed when administering SIT.

Aplicación de la inmunoterapia en Cataluña / Application of immunotherapy in Catalonia (Spain)

Objetivos: Encuesta realizada con el objetivo de conocer la situación actual y la opinión de los hospitales públicos y privados de Cataluña en relación a la utilización de la inmunoterapia específica (ITE) en el tratamiento de las enfermedades alérgicas, la pauta de administración de la ITE y la creación de Unidades de ITE. Métodos y resultados: Se envió por correo postal y/o electrónico una encuesta con 8 preguntas que estaba dirigida a los responsables de la unidad de alergología de 24 hospitales públicos y privados de Cataluña. Han contestado un total de 18 hospitales. La vía de administración de ITE más utilizada es la subcutánea (89,4 por ciento, D.E. 9,05) y la pauta de administración más seguida es la clásica (77,2 por ciento, D.E. 24,9). La mayoría de los hospitales (83,3 por ciento) consideran como una ventaja la creación de Unidades de ITE, pero sólo un 44 por ciento de los hospitales contestaron que en su centro sería posible crearlas. Conclusiones: Los resultados de la encuesta permiten conocer la aplicación de la ITE en Cataluña y poner de manifiesto algunos aspectos pendientes de establecer en este tipo de tratamiento como es la pauta de dosificación ideal y la vigilancia que requiere la administración de ITE (AU)

Background: The aim of this study was to determine the use of specific immunotherapy (SIT) in public and private hospitals in Catalonia (Spain) in the management of respiratory allergic diseases and opinions about this treatment through a questionnaire. SIT dosage schedules and the creation of immunotherapy units were also investigated. Methods and results: A questionnaire containing eight items was sent by post and/or electronic mail to the heads of allergy units in 24 public and private hospitals in Catalonia. A total of 18 hospitals responded. The most commonly used route of administration was subcutaneous (89.4 %, SD 9.05) and the most widely used dosage schedule was the classical schedule (77.2 %, SD 24.9). Most of the hospitals (83.3 %) believed that immunotherapy units were an advantage but only 44 % of them believed that their creation was feasible. Conclusions: The results of this survey identify the application of SIT in Catalonia and reveal certain features of this treatment that remain to be established such as the optimal dosage schedule and the precautions that should be followed when administering SIT (AU)

Anafilaxia en el fin de año / Anaphylaxis at the end of the year

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Reacción de hipersensibilidad retardada en el postoperatorio de una histerectomía / Retarded hypersensitivity reaction after hysterectomy

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Dermatitis de contacto por paladio contenido en una prótesis dental / Contact dermatitis by palladium content in a dental prothesis

Presentamos a una paciente de 67 años con intolerancia a una prótesis dental extraíble de metal-metacrilato y con paladio como única positividad a las 48 y 96 h. Dadas las pruebas epicutáneas efectuadas se descarta cualquier otra positividad, y por tanto ninguna reacción cruzada con níquel, cobalto u otros metales como el cromo, el vanadio, el cobre, el cadmio, la plata, el galio, el iridio, etc (AU)

We present a patient 67 years old woman with symptoms of contact dermatitis related with dental prostheses. The patch-test showed a unique positivity to palladium, without cross reactions to niekel, cobalts or another metals how copper, iridiurn, vanadium, etc (AU)

Dermatitis de contacto por 1,2-dibromo-2, 4-dicianobutano (metildibromoglutaronitrilo) contenido en el calzado / Contact dermatitis by 1, 2-dibromo-2, 4-dicyanobutane content in shoes

Presentamos el caso de un eccema de contacto alérgico por 1,2-dibromo-2,4-dicianobutano, conservante muy utilizado en cosméticos, aceites de corte, adhesivos, pigmentos, pinturas, detergentes, emulsiones de látex, etc., que no había sido referido hasta ahora como alergeno del calzado y no se halla en las baterías de alergenos destinadas al estudio de dermatitis alérgicas por calzado (AU)

We present an allergic contact dermatitis by 1,2-dibromo-2,4-dieyanobutane; a preservative used in cosmetics, oils and cooling fluids, paints, pigments, plastics and glues, etc. This preservative hasn't been referred until now as allergen from shoes and isn't in the series used to study the allergic contact dermatitis by shoes (AU)

[Transmural flow of D-galactose in the jejunum of young rats using a new perfusion chamber]. / Flujos transmurales de D-galactosa en yeyuno de ratas jóvenes con una nueva cámara de perfusión.

The chamber used allows the simultaneous but separated incubation of two intestinal segments (approximately 4 cm in length) in vitro and is especially suited for its application to studies on young animals. Segments are perfused with the help of a peristaltic pump (6 ml/h) without recycling. D-galactose fluxes across rat jejunum have been studied in everted jejunal segments from 19-21 day-old rats. Transmural fluxes (JmsGal) were determined using four external mucosal galactose concentrations (0.2, 2, 10 and 20 mM). The ratios of passive JmsGal were 1 : 11 : 49.7 : 96.7. Those due to active transport of the substrate were 1 : 7.1 : 14.6 : 18.8, indicating saturation. The active component of total JmsGal fluxes was 80%, 72%, 54% and 44%, respectively. Comparison of transmural galactose fluxes in noneverted segments from 20 day-old (suckling) and 25 day-old rats, showed that there is a marked reduction in both passive and active components of substrate flux across the intestine at the time of weaning.